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A comparative histological evaluation of the biocompatibility of materials used in apical surgery
Author(s) -
Sousa C. J. A.,
Loyola A. M.,
Versiani M. A.,
Biffi J. C. G.,
Oliveira R. P.,
Pascon E. A.
Publication year - 2004
Publication title -
international endodontic journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.988
H-Index - 119
eISSN - 1365-2591
pISSN - 0143-2885
DOI - 10.1111/j.1365-2591.2004.00861.x
Subject(s) - biocompatibility , mineral trioxide aggregate , biocompatible material , dentistry , materials science , zinc oxide eugenol , implant , biomedical engineering , resorption , medicine , surgery , root canal , pathology , metallurgy
Aim To evaluate the biological properties of a variety of materials that could be used in apical surgery. Methodology The intraosseous implant technique recommended by the FDI (1980) and ADA (1982) was used to test the following materials: zinc oxide‐eugenol (ZOE), mineral trioxide aggregate (MTA), and Z‐100 light‐cured composite resin. Thirty guinea‐pigs, 10 for each material, divided into experimental periods of 4 and 12 weeks, received one implant on each side of the lower jaw symphysis. The connective tissue response alongside the lateral wall outside the cup served as a negative control for the technique. At the end of the observation periods, the animals were killed and the specimens prepared for routine histological examination to evaluate their biocompatibility. Results The reaction of the tissue to the materials diminished with time. The ZOE cement was highly toxic during the 4‐week experimental period, but this profile changed significantly after 12 weeks, when it showed biocompatible characteristics. MTA and Z‐100 showed biocompatibility in this test model at both time periods. Conclusions MTA and Z‐100 composite were biocompatible at 4 and 12 weeks in this experimental model.