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Tissue responses assessed by intramuscular implantation
Author(s) -
REID R. J.,
WILSON D. F.,
CHAU K. K.,
HEITHERSAY G. S.,
HEIJKOOP P. S.
Publication year - 1992
Publication title -
international endodontic journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.988
H-Index - 119
eISSN - 1365-2591
pISSN - 0143-2885
DOI - 10.1111/j.1365-2591.1992.tb00750.x
Subject(s) - connective tissue , implant , von kossa stain , capsule , foreign body giant cell , giant cell , root canal , materials science , medicine , anatomy , biomedical engineering , dentistry , pathology , surgery , chemistry , biology , biochemistry , alkaline phosphatase , botany , enzyme
Summary Freshly mixed polymerized Hydron root canal filling material, fully set AH26 and Teflon were implanted in the quadriceps muscle of guinea pigs and assessed his‐tologically at 2 days, 1, 2 , 3, 12 and 26 weeks after implantation. All materials were characterized by peri‐implant fibrous connective tissue capsule formation. Von Kossa‐positive calcific material was observed at the implant‐tissue interface of Hydron implants. The amount of apparently calcified material increased with time. Inflammation was not a prominent tissue response for any of the test materials, nor was a foreign body giant cell response.