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Identification of alpha 2 adrenoceptors in the blood vessels of the dental pulp
Author(s) -
IBRICEVIC H.,
HEYERAAS K. J.,
JUHAS E. PASIC,
HAMAMDZIC M.,
DJORDJEVIC N.,
KRNIC J.
Publication year - 1991
Publication title -
international endodontic journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.988
H-Index - 119
eISSN - 1365-2591
pISSN - 0143-2885
DOI - 10.1111/j.1365-2591.1991.tb00137.x
Subject(s) - phentolamine , guanabenz , vasoconstriction , alpha (finance) , antagonist , medicine , chloralose , adrenergic receptor , pharmacology , blood pressure , agonist , receptor , surgery , construct validity , patient satisfaction
Summary. Using selective agonists and antagonists of alpha, adrenoceptors, attempts were made to identify the subtype alphaj adrenoceptors in the blood vessels of the canine dental pulp. In chloralose‐anaesthetized dogs, intra‐arterial administration of noradrenaline and guanabenz in different doses produced a dose‐related pulpal vasoconstriction which was measured using hydrogen‐gas clearance. The vasoconstrictor response to noradrenaline was inhibited by phentolamine, a non‐selective alpha adrenoceptor antagonist. The response to guanabenz was inhibited by rauwoiscine, a highly selective alpha, adrenoceptor antagonist. The results demonstrated that alpha, adrenoceptors are present in the blood vessels of dog dental pulp.