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Characterization of two types of human oral fibroblast with a potential application to cellular toxicity studies: tooth pulp fibroblasts and buccal mucosa fibroblasts
Author(s) -
ARENHOLTBINDSLEV D.,
BLEEG H.
Publication year - 1990
Publication title -
international endodontic journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.988
H-Index - 119
eISSN - 1365-2591
pISSN - 0143-2885
DOI - 10.1111/j.1365-2591.1990.tb00844.x
Subject(s) - buccal administration , buccal mucosa , oral mucosa , fibroblast , lactate dehydrogenase , acid phosphatase , cell growth , in vitro , alkaline phosphatase , pulp (tooth) , cell , biology , dentistry , microbiology and biotechnology , enzyme , chemistry , biochemistry , medicine , anatomy , oral cavity
Summary. Cultures of human oral buccal mucosa fibroblasts and human tooth pulp fibroblasts were established and grown under standard routine conditions. The biological characteristics of cell proliferation, growth pattern, cell morphology and enzyme release (lactate dehydrogenase and acid phosphatase) were studied. Under the same standard in vitro conditions the two cell types demonstrated different growth patterns and different levels of enzyme activity. It is suggested that differences in biological characteristics should be considered when selecting appropriate cells for lexicological studies of dental materials.