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Bactericidal effects of human neutrophils and sera on selected endodotic pathogenic bacteria in an anaerobic environment
Author(s) -
WU M. K,
HENRY C. A.,
GUTMANN J. L.
Publication year - 1990
Publication title -
international endodontic journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.988
H-Index - 119
eISSN - 1365-2591
pISSN - 0143-2885
DOI - 10.1111/j.1365-2591.1990.tb00099.x
Subject(s) - peptostreptococcus , microbiology and biotechnology , bacteroides , biology , anaerobic bacteria , phagocytosis , anaerobic exercise , fusobacterium , bacteria , streptococcus intermedius , streptococcus , physiology , genetics
Summary. Phagocytosis by normal human neutrophils and the bactericidal activity of normal human pooled serum were measured under anaerobic conditions on six endodontic pathogenic bacterial species from the genera Actmomyces, Bacteroides, Fusobacterium, Peptostreptococcus and Streptococcus . The results revealed that Actinomyces viscosus was not killed either by human neutrophils or by 20 per cent serum; Peptostreptococcus anaerobius was not killed by either 20 per cent or 95 per cent serum; and Bacteroides intermedius was susceptible to both 20 per cent and 95 per cent serum, but was not killed by neutrophils after exposure for 20 minutes. The other species showed intermediate susceptibility patterns. Such results suggest that oral pathogens vary with regard to the bactericidal effects of these two host defence mechanisms, and that this variation may at least in part explain the relative quantities of microbes recovered in certain oral infections.