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Response of rat and guinea‐pig subcutaneous tissue to implanted human roots containing collagen/hydroxyapatite preparations
Author(s) -
CALLIS P. D.,
SANTINI A.
Publication year - 1985
Publication title -
international endodontic journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.988
H-Index - 119
eISSN - 1365-2591
pISSN - 0143-2885
DOI - 10.1111/j.1365-2591.1985.tb00454.x
Subject(s) - granulation tissue , saline , guinea pig , anatomy , physiological saline , chemistry , pathology , medicine , wound healing , surgery
Summary. The root canals of extracted human roots were cleaned and enlarged. The roots were sterilized before insertion of test materials of collagen, hydroxyapatite or a mixture; saline was used as a control. The roots were implanted subcutaneously in rats or guinea‐pigs. After 30 and 180 days, the embedded roots were prepared for histological examination. In the rat, the tissue reaction was similar whether the roots were filled with collagen, collagen/hydroxyapatite or saline; there was ingrowth of granulation tissue. The canals of teeth filled with hydroxyapadte showed mature fibrous tissue around islands of the material. The response in guinea‐pigs was similar, except that the roots stimulated some bone formation.