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Genetic analysis of the xenobiotic resistance‐associated ABC gene subfamilies of the Lepidoptera
Author(s) -
Labbé R.,
Caveney S.,
Donly C.
Publication year - 2011
Publication title -
insect molecular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.955
H-Index - 93
eISSN - 1365-2583
pISSN - 0962-1075
DOI - 10.1111/j.1365-2583.2010.01064.x
Subject(s) - lepidoptera genitalia , biology , xenobiotic , gene , genetics , resistance (ecology) , computational biology , botany , ecology , biochemistry , enzyme
Abstract Some ATP‐binding cassette (ABC) transporters of subfamilies B, C and G confer resistance to xenobiotics including insecticides. We identified genes of these subfamilies expressed by the lepidopterans Trichoplusia ni and Bombyx mori . The B. mori genome includes eight, six and 13 ABC‐B , ‐C and ‐G genes, respectively, which encode P‐glycoprotein, multidrug resistance protein, MRP, and breast cancer resistance protein, BCRP, homologues. Among the ABC‐C and ‐ G subfamilies, gene duplication contributes to protein diversity. We have identified three ABC‐B and two ABC‐C T. ni genes. Analyses of the T. ni MRP ( TrnMRP ) revealed unique features, including the potential for TrnMRP4 hyperglycosylation and the alternative splicing of TrnMRP1 . Taken together, these attributes of moth multidrug resistance‐associated ABCs may confer distinct functional capacities to xenobiotic efflux.