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Molecular characterization and evolution of the repeating units of histone genes in Drosophila americana : coexistence of quartet and quintet units in a genome
Author(s) -
Nagoda N.,
Fukuda A.,
Nakashima Y.,
Matsuo Y.
Publication year - 2005
Publication title -
insect molecular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.955
H-Index - 93
eISSN - 1365-2583
pISSN - 0962-1075
DOI - 10.1111/j.1365-2583.2005.00603.x
Subject(s) - biology , gene , histone , genetics , genome , drosophila virilis , histone h1 , histone h2b , drosophila (subgenus)
Quintet and quartet repeating units of the histone genes in Drosophila americana were cloned and characterized . Nucleotide sequence analysis of the units showed that a 3175 bp unit contained the core histone genes but lacked the H1 gene (‘quartet unit’) while a 5025 bp unit contained all five histone genes (‘quintet unit’). Comparative analysis suggested that these repeating units diverged before the separation of D. americana and D. virilis . Multiple forms of H1 genes, differing by 5.8% of amino acids, were found in D. americana . The genomic organization of the histone gene family in D. americana was found to be very similar to that of D. virilis .