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A family of U1 pseudogenes in Bombyx mori may be derived from an ancestral pseudogene
Author(s) -
Vega L. R.,
Amengual J.,
Herrera R. J.
Publication year - 1994
Publication title -
insect molecular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.955
H-Index - 93
eISSN - 1365-2583
pISSN - 0962-1075
DOI - 10.1111/j.1365-2583.1994.tb00158.x
Subject(s) - pseudogene , bombyx mori , biology , genetics , gene , evolutionary biology , genome
Seven EMBL‐4 lambda clones containing U1 small nuclear RNA sequences were isolated from a Bombyx mori genomic library. Six of the seven represent unique sequences. The six unique U1 sequences exhibit fixed point 3‐end truncation. Five out of the six clones share immediate 3‐end flanking sequences while two share 5‐end flanking sequences. Fixed point 3‐end truncation and a hierarchy of shared to unique diagnostic mutations may suggest a family of U1 pseudogenes generated from a reverse‐transcribed class II pseudogene in B. mori. An ancestral ‘master’ U1 pseudogene capable of RNA‐ and/or DNA‐mediated transposition may give rise to generations of U1 pseudogenes that include the original pseudogene's flanking sequences. Identical 3‐end truncation in some of these U1 sequences can be explained by RNA self‐priming due to intra‐strand binding prior to reverse transcription.