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Chromosomal mapping of two loci affecting filarial worm susceptibility in Aedes aegypti
Author(s) -
Severson D. W.,
Mori A.,
Zhang Y.,
Christensen B. M.
Publication year - 1994
Publication title -
insect molecular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.955
H-Index - 93
eISSN - 1365-2583
pISSN - 0962-1075
DOI - 10.1111/j.1365-2583.1994.tb00153.x
Subject(s) - biology , aedes aegypti , locus (genetics) , genetics , brugia malayi , quantitative trait locus , epistasis , restriction fragment length polymorphism , genetic marker , gene mapping , chromosome , gene , larva , zoology , genotype , helminths , filariasis , botany
Two quantitative trait loci (QTL) affecting susceptibility of the mosquito Aedes aegypti to the filarial worm parasite Brugia malayi were identified using restriction fragment length polymorphism (RFLP) markers. The first locus, fsb[1,LF178], resides within a 10 cM interval on chromosome 1 and exhibits a recessive effect with respect to susceptibility. The second locus, fsb[2,LF98], resides within a 9 cM interval on chromosome 2 and exhibits an additive effect on susceptibility. Significant epistasis was detected between these loci, although the effect of fsb[2,LF98] was dependent on the genetic background of the mosquito strains. Suggestions for a standard QTL nomenclature are included.