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Mesenchymal stromal cells: a key player in ‘innate tolerance’?
Author(s) -
Dazzi Francesco,
Lopes Luciene,
Weng Ling
Publication year - 2012
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.2012.03621.x
Subject(s) - mesenchymal stem cell , microbiology and biotechnology , key (lock) , stromal cell , biology , cancer research , ecology
Summary The existence of a mesenchymal stromal cell ( MSC ) population with the main property of physically supporting parenchymal tissues has long been recognized in virtually all organs. However, it was only recently that MSC have been identified as playing a novel role in modulating inflammation. It has been extensively documented that, under particular circumstances, MSC potently impair virtually all cells of the immune system, including antigen‐presenting‐cells.