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Recent progress toward understanding the physiological function of bone marrow mesenchymal stem cells
Author(s) -
Shi Chao
Publication year - 2012
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.2012.03567.x
Subject(s) - mesenchymal stem cell , bone marrow , biology , clinical uses of mesenchymal stem cells , stem cell transplantation for articular cartilage repair , context (archaeology) , haematopoiesis , immune system , stem cell , in vivo , microbiology and biotechnology , immunology , adult stem cell , in vitro , endothelial stem cell , paleontology , biochemistry
Summary Mesenchymal stem cells (MSCs) are multipotent cells that are being clinically explored as regenerative therapeutics. Cultured MSCs secrete various modulatory factors, which contribute to the immunosuppressive effects of transplanted MSCs as a therapy. Although the in vitro phenotype of MSCs has been well characterized, identification of MSCs in vivo is made difficult by the lack of specific markers. Current advances in murine MSC research provide valuable tools for studying the localization and function of MSCs in vivo . Recent findings suggest that MSCs exert diverse functions depending on tissue context and physiological conditions. This review focuses on bone marrow MSCs and their roles in haematopoiesis and immune responses.