The interleukin‐17 cytokine family: critical players in host defence and inflammatory diseases | Zendy

Pappu Rajita | Zendy; RamirezCarrozzi Vladimir | Zendy; Sambandam Arivazhagan | Zendy

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The interleukin‐17 cytokine family: critical players in host defence and inflammatory diseases

Author(s) -

Pappu Rajita,

RamirezCarrozzi Vladimir,

Sambandam Arivazhagan

Publication year - 2011

Publication title -

immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.297

H-Index - 133

eISSN - 1365-2567

pISSN - 0019-2805

DOI - 10.1111/j.1365-2567.2011.03465.x

Subject(s) - immunology , biology , inflammation , cytokine , pathogenesis , acquired immune system , innate immune system , interleukin , immunity , receptor , interleukin 17 , immune system , genetics

Summary The interleukin‐17 (IL‐17) cytokines, IL‐17A to IL‐17F, are emerging as critical players in host defence responses and inflammatory diseases. Substantial data support the role of these proteins in innate and adaptive immunity. Of these family members, IL‐17A, IL‐17F and IL‐17E have been the best studied. Both IL‐17A and IL‐17F contribute to the host response to extracellular bacteria and fungi, and IL‐17E has been shown to play a role in parasitic infections. In addition, numerous pre‐clinical and clinical studies link these proteins to the pathogenesis of inflammatory diseases, and a number of therapeutic programmes targeting these family members are in clinical development. This review will highlight the cellular sources, receptors/target cells, and role in inflammation of these and the less‐characterized family members, IL‐17B, IL‐17C and IL‐17D.

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