Premium
The interleukin‐17 cytokine family: critical players in host defence and inflammatory diseases
Author(s) -
Pappu Rajita,
RamirezCarrozzi Vladimir,
Sambandam Arivazhagan
Publication year - 2011
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.2011.03465.x
Subject(s) - immunology , inflammation , biology , pathogenesis , cytokine , interleukin , innate immune system , acquired immune system , receptor , immune system , genetics
Summary The interleukin‐17 (IL‐17) cytokines, IL‐17A to IL‐17F, are emerging as critical players in host defence responses and inflammatory diseases. Substantial data support the role of these proteins in innate and adaptive immunity. Of these family members, IL‐17A, IL‐17F and IL‐17E have been the best studied. Both IL‐17A and IL‐17F contribute to the host response to extracellular bacteria and fungi, and IL‐17E has been shown to play a role in parasitic infections. In addition, numerous pre‐clinical and clinical studies link these proteins to the pathogenesis of inflammatory diseases, and a number of therapeutic programmes targeting these family members are in clinical development. This review will highlight the cellular sources, receptors/target cells, and role in inflammation of these and the less‐characterized family members, IL‐17B, IL‐17C and IL‐17D.