Premium
Nature and nurture: T‐cell receptor‐dependent and T‐cell receptor‐independent differentiation cues in the selection of the memory T‐cell pool
Author(s) -
Kim Chulwoo,
Williams Matthew A.
Publication year - 2010
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.2010.03338.x
Subject(s) - biology , t cell receptor , clone (java method) , cd8 , major histocompatibility complex , t cell , antigen , microbiology and biotechnology , cellular differentiation , cytotoxic t cell , immune system , immunology , genetics , in vitro , gene
Summary The initiation of a T‐cell response begins with the interaction of an individual T‐cell clone with its cognate antigen presented by MHC. Although the strength of the T‐cell receptor (TCR) –antigen–MHC (TCR‐pMHC) interaction plays an important and obvious role in the recruitment of T cells into the immune response, evidence in recent years has suggested that the strength of this initial interaction can influence various other aspects of the fate of an individual T‐cell clone and its daughter cells. In this review, we will describe differences in the way CD4 + and CD8 + T cells incorporate antigen‐driven differentiation and survival signals during the response to acute infection. Furthermore, we will discuss increasing evidence that the quality and/or quantity of the initial TCR‐pMHC interaction can drive the differentiation and long‐term survival of T helper type 1 memory populations.