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An integrated view of the regulation of NKG2D ligands
Author(s) -
SternGinossar Noam,
Mandelboim Ofer
Publication year - 2009
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.2009.03147.x
Subject(s) - nkg2d , receptor , microbiology and biotechnology , biology , computational biology , genetics , cytotoxicity , in vitro
Summary NKG2D is one of the best characterized activating receptors and is expressed on natural killer cells and on various T‐cell subsets. This receptor recognizes several different ligands that are induced by cellular stresses. In this review, we described the mechanisms controlling the expression of NKG2D ligands, with the emphasis on post‐transcriptional and post‐translational regulation.