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Th9 and allergic disease
Author(s) -
Soroosh Pejman,
Doherty Taylor A.
Publication year - 2009
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.2009.03114.x
Subject(s) - immunology , interleukin 9 , disease , cytokine , t helper cell , population , immune system , allergic inflammation , acquired immune system , biology , interleukin 4 , inflammation , interleukin , t cell , medicine , pathology , environmental health
Summary Helper CD4 + T‐cell subsets have improved our understanding of adaptive immunity in humans and in animal models of disease. These include T helper type 1 (Th1), Th2 and the interleukin‐17 (IL‐17) ‐producing population ‘Th17’. Th2 cells have been described as orchestrating the immune response in allergic disease based on studies with patient samples and animal models. The cytokine IL‐9 has largely been regarded as a Th2 cytokine that makes multifocal contributions to allergic disease. Recent data suggest that under certain conditions relevant to chronic disease (IL‐4 and transforming growth factor‐β), a distinct population of IL‐9‐producing ‘Th9’ helper T cells can exist. The contribution of Th9 cells in allergic disease is currently unknown, and this review will propose a model for how these cells may regulate chronic allergic inflammation.