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Endosomal processing for antigen presentation mediated by CD1 and Class I major histocompatibility complex: roads to display or destruction
Author(s) -
Boes Marianne,
Stoppelenburg Arie J.,
Sillé Fenna C. M.
Publication year - 2009
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.2009.03078.x
Subject(s) - antigen processing , antigen presentation , cross presentation , major histocompatibility complex , antigen , mhc class i , cd1 , biology , transporter associated with antigen processing , mhc restriction , endosome , mhc class ii , cd8 , immune system , microbiology and biotechnology , immunology , t cell , natural killer t cell , intracellular
Summary The presentation of antigen in a form that can be recognized by T lymphocytes of the immune system requires antigen processing and association of antigen‐derived fragments with molecules encoded by the major histocompatibility complex (MHC) locus or by the CD1 locus. Much emphasis on antigen processing and presentation in the last decades has focused on what we consider ‘conventional routes’ of antigen processing and presentation, whereby extracellular antigens are processed for presentation via Class II MHC complexes and cytosolic antigens are presented as peptide–Class I MHC complexes. We here highlight two other pathways in myeloid dendritic cells, those of lipid antigen presentation in association with CD1 and of peptide cross‐presentation via Class I MHC complexes. Some pathogens evade immune recognition through inhibition of antigen presentation of phagosomal origin. Deviations in endosomal antigen processing and presentation are also seen in individuals suffering from glycosphingolipid lysosomal lipid storage diseases. We summarize recent developments in the endosomal antigen processing and presentation pathway, for display as lipid–CD1 complexes to natural killer T cells and as peptide–Class I MHC complexes to CD8 T cells.