Premium
Astrocyte elevated gene‐1 (AEG‐1) is induced by lipopolysaccharide as toll‐like receptor 4 (TLR4) ligand and regulates TLR4 signalling
Author(s) -
Khuda Imtiaz IE.,
Koide Naoki,
Noman Abu S. M.,
Dagvadorj Jargalsaikhan,
Tumurkhuu Gantsetseg,
Naiki Yoshikazu,
Komatsu Takayuki,
Yoshida Tomoaki,
Yokochi Takashi
Publication year - 2009
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.2009.03063.x
Subject(s) - tlr4 , proinflammatory cytokine , lipopolysaccharide , astrocyte , tumor necrosis factor alpha , biology , toll like receptor , receptor , cytokine , nf κb , microbiology and biotechnology , inflammation , signal transduction , immunology , cancer research , endocrinology , innate immune system , biochemistry , central nervous system
Summary Astrocyte elevated gene‐1 (AEG‐1) is induced by human immunodeficiency virus 1 (HIV‐1) infection and involved in tumour progression, migration and invasion as a nuclear factor‐κB (NF‐κB) ‐dependent gene. The involvement of AEG‐1 on lipopolysaccharide (LPS) ‐induced proinflammatory cytokine production was examined. AEG‐1 was induced via NF‐κB activation in LPS‐stimulated U937 human promonocytic cells. AEG‐1 induced by LPS subsequently regulated NF‐κB activation. The prevention of AEG‐1 expression inhibited LPS‐induced tumour necrosis factor‐α and prostaglandin E 2 production. The AEG‐1 activation was not induced by toll‐like receptor ligands other than LPS. Therefore, AEG‐1 was suggested to be a LPS‐responsive gene and involved in LPS‐induced inflammatory response.