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Access to immunology through the Gene Ontology
Author(s) -
Lovering Ruth C.,
Camon Evelyn B.,
Blake Judith A.,
Diehl Alexander D.
Publication year - 2008
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.2008.02940.x
Subject(s) - ontology , vocabulary , annotation , computer science , process (computing) , gene ontology , value (mathematics) , biology , gene , artificial intelligence , linguistics , genetics , epistemology , philosophy , gene expression , machine learning , operating system
Summary The Gene Ontology (GO) is widely recognized as the premier tool for the organization and functional annotation of molecular aspects of cellular systems. However, for many immunologists the use of GO is a very foreign concept. Indeed, as a controlled vocabulary, GO can almost be considered a new language, and it can be difficult to appreciate the use and value of this approach for understanding the immune system. This review reflects on the application of GO to the field of immunology and explains the process of GO annotation. Finally, this review hopes to inspire immunologists to invest time and energy in improving both the content of the GO and the quality of GO annotations associated with genes of immunological interest.