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Soluble CD38 significantly prolongs the lifespan of memory B‐cell responses
Author(s) -
Liu Xue Q.,
Hart Derek N. J.,
MacPherson Gordon G.,
Good Michael F.,
Wykes Michelle N.
Publication year - 2008
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.2008.02914.x
Subject(s) - cd38 , germinal center , spleen , adoptive cell transfer , biology , antigen , microbiology and biotechnology , immunology , b cell , chemistry , antibody , t cell , stem cell , immune system , cd34
Summary The development and maintenance of memory B cells (MBC) is dependent on germinal centres (GC) with follicular dendritic cell (FDC) networks. We have previously shown that FDC networks within GC of the spleen express a novel ligand for CD38 and that the administration of soluble CD38 induces an expansion of these cellular structures. We therefore used adoptive transfer studies to investigate whether the expansion of FDC networks with soluble CD38 affected the generation and maintenance of antigen‐specific MBC. These studies found that the administration of soluble CD38 significantly extended the period after which MBC could be activated and that the frequencies of these cells also were increased. In conclusion, soluble CD38 appears to significantly extend the lifespan of antibody memory by increasing the numbers of MBC.