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Regulatory T cells and tumour immunity – observations in mice and men
Author(s) -
Gallimore Awen,
Godkin Andrew
Publication year - 2008
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.2007.02748.x
Subject(s) - immunosurveillance , immune system , immunology , context (archaeology) , tumor immunology , biology , immunity , immunotherapy , il 2 receptor , population , cancer immunotherapy , cancer research , t cell , medicine , paleontology , environmental health
Summary An enormous body of work supports a role for CD4 + CD25 + regulatory cells (Tregs) in shaping the immune response to tumours. Indeed, there is evidence that the cells impede effective tumour immunosurveillance, inhibit vaccine‐induced antitumour immune responses and promote tumour progression. Studies exploring the impact of Tregs on tumour development are discussed in the context of manipulating this T‐cell population for the purpose of cancer immunotherapy.