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Genetic control of immune‐mediated necrosis of Mycobacterium avium granulomas
Author(s) -
Flórido Manuela,
Appelberg Rui
Publication year - 2006
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.2006.02350.x
Subject(s) - necrosis , granuloma , congenic , biology , virulence , immune system , mycobacterium , tumor necrosis factor alpha , immunology , microbiology and biotechnology , strain (injury) , pathology , gene , medicine , bacteria , genetics , anatomy
Summary Intravenous infection of C57BL/6 and C57BL/10 mice with low doses of a highly virulent strain of Mycobacterium avium (ATCC 25291) led to the development of granulomas that underwent necrosis. In contrast, neither BALB/c nor DBA/1 mice developed granuloma necrosis after such infection despite a similar course of mycobacterial proliferation. Studies with C57BL/10 mice congenic for the Hc locus revealed that an intact complement C5 gene is required for granuloma necrosis. On the other hand, genetic disruption of the interleukin‐10 gene in BALB/c mice made this strain susceptible to granuloma necrosis.