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Drinking a lot is good for dendritic cells
Author(s) -
Norbury Christopher C.
Publication year - 2006
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.2006.02335.x
Subject(s) - pinocytosis , internalization , endocytic cycle , microbiology and biotechnology , endosome , immune system , endocytosis , biology , context (archaeology) , antigen presenting cell , antigen , dendritic cell , chemistry , immunology , cell , t cell , biochemistry , paleontology , intracellular
Summary Macropinocytosis is the actin‐dependent formation of large vesicles, which allow the internalization of large quantities of fluid‐phase solute. In the majority of cells examined, an exogenous stimulus is required to induce the initiation of this endocytic pathway. However, dendritic cells are thought to constitutively macropinocytose large quantities of exogenous solute as part of their sentinel function. In this review we discuss the evidence that dendritic cells macropinocytose exogenous solute and subsequently present antigenic peptides derived from internalized material to T cells. In addition, we put these data into the context of immune surveillance in vivo .