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Chemokine control of lymphocyte trafficking: a general overview
Author(s) -
Stein Jens V.,
NombelaArrieta César
Publication year - 2005
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.2005.02183.x
Subject(s) - chemokine , chemokine receptor , immunology , effector , biology , lymphocyte , avidity , integrin , leukocyte trafficking , microbiology and biotechnology , immune system , receptor , antibody , genetics
Summary Chemokines are a large family of small, generally secreted polypeptides which guide lymphocyte movement throughout the body by controlling integrin avidity and inducing migration. Here, we look at recent, exciting findings on chemokine function throughout lymphocyte development and co‐ordinated T and B cell migration during immune responses. Finally, we will review data on the regional control of immunity by tissue‐specific chemokine receptors on effector/memory lymphocytes.