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Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES‐62
Author(s) -
Goodridge Helen S.,
Stepek Gillian,
Harnett William,
Harnett Margaret M.
Publication year - 2005
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.2005.02167.x
Subject(s) - phosphorylcholine , biology , immune system , secretion , nematode , signal transduction , microbiology and biotechnology , glycoprotein , immunology , ecology , biochemistry
Summary Secretion of immunomodulatory molecules is a key strategy employed by pathogens to enable their survival in host organisms. For example, arthropod‐transmitted filarial nematodes, which achieve longevity within the infected host by suppressing and modulating the host immune response, produce excretory–secretory (ES) products that have been demonstrated to possess immunomodulatory properties. In this review we discuss the immunomodulatory effects of the phosphorylcholine‐containing filarial nematode‐secreted glycoprotein ES‐62 and describe the intracellular signal transduction pathways it targets to achieve these effects.