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Human CD8 + T cells specific for influenza A virus M1 display broad expression of maturation‐associated phenotypic markers and chemokine receptors
Author(s) -
Hoji Aki,
R. Rinaldo Charles
Publication year - 2005
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.2005.02135.x
Subject(s) - biology , c c chemokine receptor type 6 , cytotoxic t cell , phenotype , ccl5 , chemokine receptor , cd8 , microbiology and biotechnology , virology , il 2 receptor , immunology , chemokine , antigen , immune system , gene , genetics , in vitro
Summary To define the role of memory T cells in a non‐persistent viral infection, we have delineated the phenotype of memory CD8 + T cells specific for influenza A virus (FluA; matrix protein M1 58−66 ) based on the expression of several memory/effector lineage markers and relevant chemokine receptors. We found a majority of FluA‐specific CD8 + T cells expressed CD27 and CD28, and variably expressed CD45RA, CD62L, CD94 and granzyme A. A majority of FluA‐specific CD8 + T cells expressed high levels of CXCR3, and moderate levels of CCR5 and CXCR4, whereas a limited proportion expressed CCR7, CCR6 and CXCR5. A phenotypic profile based on these observations showed that there are both immature and mature memory CD8 + T cells specific for FluA.