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T‐cell homeostasis in mice exposed to airborne xenobiotics
Author(s) -
Drela Nadzieja,
Bień Justyna,
Kozłowska Ewa
Publication year - 2005
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.2005.02092.x
Subject(s) - homeostasis , progenitor cell , biology , xenobiotic , progenitor , thymocyte , microbiology and biotechnology , immune system , cell , t cell , immunology , stem cell , biochemistry , enzyme
Summary Many effects of environmental toxic agents contribute to the deregulation of immune system homeostasis. Here we demonstrate that the effect of airborne suspended matter (ASM) on the generation of mouse T cells is reversible. This reversal can be achieved by an active process that returns the T cells to homeostasis and does not result from the simple effect of ASM deprivation. An accelerated development of thymocytes and increased influx of T‐cell progenitors to the thymus in mice exposed to environmental xenobiotics has been postulated. This hypothesis has been confirmed by parallel increases in the percentages of single‐positive and triple‐negative thymocytes. Enhanced expression of thymocyte surface markers related to positive selection has also been observed. The pathway of T‐cell progenitor development is favoured in the bone marrow of mice exposed to ASM.