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Signal transducer and activator of transcription (STAT) signalling and T‐cell lymphomas
Author(s) -
Mitchell Tracey J.,
John Susan
Publication year - 2005
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.2005.02091.x
Subject(s) - stat protein , stat , jak stat signaling pathway , transcription factor , microbiology and biotechnology , signal transduction , biology , cancer research , stat4 , signalling , stat6 , transcription (linguistics) , stat3 , gene , genetics , receptor tyrosine kinase , linguistics , philosophy
Summary Interaction of cytokines with their cognate receptors leads to the activation of latent transcription factors – the signal transducers and activators of transcription (STAT) proteins – whose biological activities ultimately regulate many critical aspects of cell growth, survival and differentiation. Dysregulation of the JAK‐STAT pathway is frequently observed in many primary human tumours, reflecting the importance of this pathway in the maintenance of cellular integrity. Here we review the current progress in STAT structure and function, and the contribution of STAT signalling to the pathogenesis of T‐cell lymphomas.