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Complement receptors regulate lipopolysaccharide‐induced T‐cell stimulation
Author(s) -
Kaya Ziya,
Tretter Theresa,
Schlichting Jens,
Leuschner Florian,
Afanasyeva Marina,
Katus Hugo A.,
Rose Noel R.
Publication year - 2005
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.2004.02113.x
Subject(s) - lipopolysaccharide , il 2 receptor , microbiology and biotechnology , complement receptor , immune system , biology , cytotoxic t cell , t cell , antigen presenting cell , interleukin 21 , acquired immune system , cd8 , receptor , immunology , chemistry , complement system , biochemistry , in vitro
Summary Complement receptors type 1 and 2 (CR1 (CD35)/CR2 (CD21)) are known to enhance the adaptive immune response. In mice, CR1/CR2 are expressed on B cells, follicular dendritic cells, and activated granulocytes. Recently, we showed that a subset of CD44 high and CD62L low T cells also expresses CR1 and CR2. We now report that CR1/CR2 are detectable on both CD4 + and CD8 + subsets of T cells. Lipopolysaccharide (LPS) from Gram‐negative bacteria causes polyclonal activation of B cells and stimulation of macrophages and other antigen‐presenting cells. We further demonstrate that LPS induced marked up‐regulation of CD25 and CD69 on T cells from CR1/CR2 sufficient (Cr +/+ ), but significantly lower up‐regulation on T cells from CR1/CR2 deficient (Cr –/– ) mice. These findings point to a novel mechanism by which CR1/CR2 modulates the activation of T cells by LPS.