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The potential for Toll‐like receptors to collaborate with other innate immune receptors
Author(s) -
Mukhopadhyay Subhankar,
Herre Jurgen,
Brown Gordon D.,
Gordon Siamon
Publication year - 2004
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.2004.01941.x
Subject(s) - innate immune system , receptor , biology , immune system , immune receptor , immunology , toll , toll like receptor , pattern recognition receptor , microbiology and biotechnology , genetics
Summary Cells of the innate immune system express a large repertoire of germ‐line encoded cell‐surface glycoprotein receptors including Toll‐like receptors (TLRs). TLRs recognize conserved motifs on microbes and induce inflammatory signals. Evidence suggests that individual members of the TLR family or other non‐TLR surface antigens either physically or functionally interact with each other and cumulative effects of these interactions instruct the nature and outcome of the immune response to a particular pathogen.