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The influence of follicular migration on T‐cell differentiation
Author(s) -
Smith Karen M.,
Brewer James M.,
Mowat Allan Mci.,
Ron Yacov,
Garside Paul
Publication year - 2004
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.2004.01813.x
Subject(s) - follicular phase , microbiology and biotechnology , follicular cell , biology , endocrinology
Summary The sequence of events that leads to the development of a T‐dependent B‐cell response has been studied for many years and much attention has focused on the importance of these interactions for the B cell and the antibody response. While a role for B cells in T‐cell memory has been demonstrated, the cellular and molecular mechanisms underlying this are unclear and the importance for T cells to migrate into follicles and interact with B cells has received relatively little attention. These interactions between T and B lymphocytes are facilitated by a co‐ordinated series of migration events within lymph nodes and here we propose that this migration and these events are essential for the terminal differentiation of all CD4 + T cells and without it tolerance may result.