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Modulation of immune dysfunction during murine leukaemia retrovirus infection of old mice by dehyroepiandrosterone sulphate (DHEAS)
Author(s) -
ARAGHINIKNAM M.,
LIANG B.,
ZHANG Z.,
ARDESTANI S. K.,
WATSON R. R.
Publication year - 1997
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.1997.00344.x
Subject(s) - immune dysfunction , immune system , retrovirus , immune modulation , immunology , medicine , virology , biology , virus
SUMMARY Ageing, leukaemia and acquired immune deficiency syndrome (AIDS) are conditions with dysregulated cytokine production. As dehydroepiandrosterone sulphate (DHEAS) restored normal cytokine production in old mice its effects on retrovirally infected old mice were investigated. Retrovirus infection and ageing‐induced immune dysfunction. Murine retrovirus‐infected old C57BL/6 female mice consumed 0·22 or 0·44 μg of DHEAS/mouse/day beginning 2 weeks postinfection for 10 weeks. DHEAS largely prevented the retrovirus‐induced reduction in T‐cell and B‐cell mitogenesis. DHEAS supplement prevented loss of cytokines [interleukin‐2 (IL‐2) and interferon‐γ] secretion by mitogen‐stimulated splenocytes representing T helper 1 (Th1) cell phenotypes. It also suppressed the retrovirus‐induced, excessive production of cytokines (IL‐6 and IL‐10) by Th2 cells. The highest dose of DHEAS reduced IL‐6 production by splenocytes from uninfected old mice by 75% while increasing their IL‐2 secretion by nearly 50%. Thus immune dysfunction induced by ageing, even when exacerbated by murine retrovirus infection, was largely prevented by DHEAS.