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Diffuse large B cell lymphoma with an interfollicular pattern of proliferation shows a favourable prognosis: a study of the Osaka Lymphoma Study Group
Author(s) -
Wada Naoki,
Zaki Mona A A,
Kohara Masaharu,
Ogawa Hiroyasu,
Sugiyama Haruo,
Nomura Shosaku,
Matsumura Itaru,
Hino Masayuki,
Kanakura Yuzuru,
Inagaki Hiroshi,
Morii Eiichi,
Aozasa Katsuyuki
Publication year - 2012
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2011.04161.x
Subject(s) - lymphoma , diffuse large b cell lymphoma , pathology , immunohistochemistry , stage (stratigraphy) , cd68 , histopathology , medicine , lymph node , cd163 , marginal zone , biology , b cell , antibody , immunology , macrophage , in vitro , paleontology , biochemistry
Wada N, Zaki M A A, Kohara M, Ogawa H, Sugiyama H, Nomura S, Matsumura I, Hino M, Kanakura Y, Inagaki H, Morii E & Aozasa K
(2012) Histopathology 60, 924–932
Diffuse large B cell lymphoma with an interfollicular pattern of proliferation shows a favourable prognosis: a study of the Osaka Lymphoma Study Group Aims: ]Diffuse large B cell lymphoma (DLBCL) occasionally shows an interfollicular pattern of proliferation (DLBCL‐IF) preserving lymphoid follicles. In this study, clinicopathological findings in 31 cases of DLBCL‐IF were analysed. Methods and results: The study group comprised 20 males and 11 females, with ages ranging from 41 to 87 (median 69) years. The primary site was lymph node in 25 cases, and unknown in six due to advanced stage at diagnosis. Eight cases were clinical Stage I, 10 were Stage II, four Stage III, and nine Stage IV. A polymorphous pattern of proliferation containing large B cells and inflammatory cells was found in about 60% of cases. The overall survival rate of the DLBCL‐IF patients was better than that of a DLBCL control group (log‐rank test; P < 0.05). Multivariate analysis revealed that an interfollicular pattern of proliferation showed marginal significance for favourable prognosis ( P = 0.069). Immunohistochemical double staining with antibodies for HLA‐DR/CD68 (markers for M1‐tumour‐associated macrophage [M1‐TAM]) or CD163/CD68 (M2‐TAM) revealed that all DLBCL‐IF patients with a low M2 count were alive at the end of observation. Conclusions: These findings suggest that DLBCL‐IF is a clinicopathological entity distinct from ordinary DLBCL. The possible origin of tumour cells in DLBCL‐IF from marginal zone B cells is discussed.