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Discovered on gastrointestinal stromal tumours 1 (DOG1) expression in non‐gastrointestinal stromal tumour (GIST) neoplasms
Author(s) -
Hemminger Jessica,
Iwenofu O Hans
Publication year - 2012
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2011.04150.x
Subject(s) - pathology , leiomyosarcoma , gist , sarcoma , synovial sarcoma , acinic cell carcinoma , malignant peripheral nerve sheath tumor , clear cell sarcoma , stromal tumor , schwannoma , pdgfra , medicine , immunohistochemistry , stromal cell , biology , carcinoma , mucoepidermoid carcinoma
Hemminger J & Iwenofu O H
(2012) Histopathology 61, 170–177 Discovered on gastrointestinal stromal tumours 1 (DOG1) expression in non‐gastrointestinal stromal tumour (GIST) neoplasms Aims: To further characterize discovered on GIST1 (DOG1) antibody clone K9 expression in a broad range of mesenchymal and epithelial tumours. Methods and results: Formalin‐fixed paraffin‐embedded sections of various tumours were stained with the anti‐DOG1 monoclonal antibody clone K9. The tumours ( n = 187) included: gastrointestinal stromal tumours (GISTs) ( n = 20); malignant melanoma ( n = 19); schwannoma ( n = 10); neurofibroma ( n = 10); leiomyosarcoma ( n = 10); low‐grade fibromyxoid sarcoma ( n = 5); angiosarcoma, ( n = 10); epithelioid sarcoma ( n = 5); clear cell sarcoma ( n = 3); synovial sarcoma ( n = 10); malignant peripheral nerve sheath tumour (MPNST) ( n = 12); alveolar soft part sarcoma ( n = 3); chordoma ( n = 5); pleomorphic undifferentiated sarcoma ( n = 5); perineurioma ( n = 4); granular cell tumour ( n = 6); acinic cell carcinoma ( n = 5); adenocarcinoma, lung ( n = 5), colon ( n = 10), endometrioid ( n = 10), prostate ( n = 10) and renal cell ( n = 10). Nineteen of 20 GISTs expressed DOG‐1 and 12 of 20 were diffusely positive (≥95%) with moderate to strong intensity. There was focal, predominantly luminal staining of colorectal (three of 10), endometrioid (four of 10) and acinic cell carcinomas (four of five). One case each of spindle cell/desmoplastic melanoma (2+), schwannoma (trace) and MPNST (2+) showed DOG‐1 expression. Conclusions: Our study supports that DOG‐1 is a highly sensitive and specific marker for GISTs and also highlights hitherto unrecognized and unusual patterns of expression in non‐mesenchymal neoplasms.