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Desmocollin 2 is a new immunohistochemical marker indicative of squamous differentiation in urothelial carcinoma
Author(s) -
Hayashi Tetsutaro,
Sentani Kazuhiro,
Oue Naohide,
Anami Katsuhiro,
Sakamoto Naoya,
Ohara Shinya,
Teishima Jun,
Noguchi Tsuyoshi,
Nakayama Hirofumi,
Taniyama Kiyomi,
Matsubara Akio,
Yasui Wataru
Publication year - 2011
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2011.03988.x
Subject(s) - immunohistochemistry , urothelial carcinoma , pathology , squamous carcinoma , carcinoma , medicine , biology , cancer , bladder cancer
Hayashi T, Sentani K, Oue N, Anami K, Sakamoto N, Ohara S, Teishima J, Noguchi T, Nakayama H, Taniyama K, Matsubara A & Yasui W
(2011) Histopathology 59 , 710–721
Desmocollin 2 is a new immunohistochemical marker indicative of squamous differentiation in urothelial carcinoma Aims: Urothelial carcinoma (UC) with squamous differentiation tends to present at higher stages than pure UC. To distinguish UC with squamous differentiation from pure UC, a sensitive and specific marker is needed. Desmocollin 2 (DSC2) is a protein localized in desmosomal junctions of stratified epithelium, but little is known about its biological significance in bladder cancer. We examined the utility of DSC2 as a diagnostic marker. Methods and results: We analysed the immunohistochemical characteristics of DSC2, and studied the relationship of DSC2 expression with the expression of the known markers uroplakin III (UPIII), cytokeratin (CK)7, CK20, epidermal growth factor receptor (EGFR), and p53. DSC2 staining was detected in 24 of 25 (96%) cases of UC with squamous differentiation, but in none of 85 (0%) cases of pure UC. DSC2 staining was detected only in areas of squamous differentiation. DSC2 expression was mutually exclusive of UPIII expression, and was correlated with EGFR expression. Furthermore, DSC2 expression was correlated with higher stage ( P = 0.0314) and poor prognosis ( P = 0.0477). Conclusions: DSC2 staining offers high sensitivity (96%) and high specificity (100%) for the detection of squamous differentiation in UC. DSC2 is a useful immunohistochemical marker for separation of UC with squamous differentiation from pure UC.