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Phospholipase A2 group IIA expression correlates with prolonged survival in gastric cancer
Author(s) -
Xing XiaoFang,
Li Hong,
Zhong XiYao,
Zhang LianHai,
Wang XiaoHong,
Liu YiQiang,
Jia ShuQin,
Shi Tao,
Niu ZhaoJian,
Peng Yong,
Du Hong,
Zhang GuiGuo,
Hu Ying,
Lu AiPing,
Li JiYou,
Chen She,
Ji JiaFu
Publication year - 2011
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2011.03913.x
Subject(s) - immunohistochemistry , cancer , intestinal metaplasia , pathology , metastasis , biology , carcinoma , biomarker , medicine , biochemistry
Xing X‐F, Li H, Zhong X‐Y, Zhang L‐H, Wang X‐H, Liu Y‐Q, Jia S‐Q, Shi T, Niu Z‐J, Peng Y, Du H, Zhang G‐G, Hu Y, Lu A‐P, Li J‐Y, Chen S & Ji J‐F
(2011) Histopathology 59 , 198–206 Phospholipase A2 group IIA expression correlates with prolonged survival in gastric cancer Aims: The secreted phospholipase A2 type IIA (PLA2G2A) gene has been identified as a modifier of intestinal adenoma multiplicity in Apc Min/+ mice. The aim of the present study was to analyse the clinical significance of PLA2G2A expression in human gastric cancer. Methods and results: Using immunohistochemistry, cytoplasmic immunoreactivity of PLA2G2A was observed in 27% (40 of 149) of gastric cancer tissues compared with negative staining in normal mucosa. The PLA2G2A expression rate in well‐differentiated carcinoma was elevated significantly compared with that in poorly differentiated carcinoma (46% versus 19%, P = 0.001). Statistical analysis also revealed that PLA2G2A expression correlated negatively with depth of mural invasion, lymph node metastasis and tumour–node–metastasis (TNM) stage ( P < 0.05). Patients with positive PLA2G2A expression showed higher 5‐year overall survival than those with negative expression ( P = 0.0004). In intestinal metaplasia, PLA2G2A was found to be abundant in Paneth cells. The coexistence of PLA2G2A and lysozyme was observed in Paneth cell‐rich gastric cancer ( P < 0.0001). Conclusions: PLA2G2A may predict survival and might be a potential biomarker for early detection and individualized therapy.