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Factors influencing reproducibility of tumour regression grading after high‐dose chemoradiation of locally advanced rectal cancer
Author(s) -
Lindebjerg Jan,
Hansborg Niels,
Ploen John,
Rafaelsen Soren,
Jorgensen Jens Christian Riis,
Jakobsen Anders
Publication year - 2011
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2011.03888.x
Subject(s) - reproducibility , grading (engineering) , medicine , colorectal cancer , nuclear medicine , regression , radiology , cancer , statistics , mathematics , civil engineering , engineering
Lindebjerg J, Hansborg N, Ploen J, Rafaelsen S, Jorgensen J C R & Jakobsen A
(2011) Histopathology 59 , 18–21 Factors influencing reproducibility of tumour regression grading after high‐dose chemoradiation of locally advanced rectal cancerAims: High‐dose chemoradiation is now considered the standard treatment of locally advanced rectal cancer. To provide feedback on the effect of this treatment, several regression grading systems have been proposed. For a grading system to be useful it has to be reproducible. The aim of this study was to test the reproducibility of a five‐point grading system, proposed originally by Mandard, and to describe the sources of disagreement. Methods and results: Tumour regression was assessed independently by two observers on 100 consecutive chemoradiated rectal cancer specimens. The grading system was extremely reproducible, with weighted and unweighted kappa values of 0.89 and 0.82, respectively. The most frequent source of disagreement was assessment of the relative amount of fibrosis. Displacement of epithelium was a minor source of disagreement. Conclusions: The five‐point grading system of Mandard is extremely reproducible.