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Topographical, morphological and immunohistochemical characteristics of carcinoma in situ of the breast involving sclerosing adenosis. Two distinct topographical patterns and histological types of carcinoma in situ
Author(s) -
Moritani Suzuko,
Ichihara Shu,
Hasegawa Masaki,
Endo Tokiko,
Oiwa Mikinao,
Shiraiwa Misaki,
Nishida Chikako,
Morita Takako,
Sato Yasuyuki,
Hayashi Takako,
Kato Aya,
Aoyama Hideaki,
Yoshikawa Kazuaki
Publication year - 2011
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2011.03792.x
Subject(s) - apocrine , pathology , immunohistochemistry , carcinoma , cyclin d1 , carcinoma in situ , in situ , ductal carcinoma , estrogen receptor , biology , immunophenotyping , breast cancer , cancer , medicine , chemistry , microbiology and biotechnology , cell cycle , flow cytometry , organic chemistry
Moritani S, Ichihara S, Hasegawa M, Endo T, Oiwa M, Shiraiwa M, Nishida C, Morita T, Sato Y, Hayashi T, Kato A, Aoyama H & Yoshikawa K
(2011) Histopathology 58 , 835–846
Topographical, morphological and immunohistochemical characteristics of carcinoma in situ of the breast involving sclerosing adenosis. Two distinct topographical patterns and histological types of carcinoma in situAim: To examine the histopathological features of 24 surgically resected carcinoma in situ (CIS) involving sclerosing adenosis (SA), with special reference to the topographical relationship between CIS and SA. Methods and results: In 13 (54%) lesions, CIS was entirely surrounded by SA (type A) and in 11 (46%), CIS involved SA at least focally but was not confined to the SA area (type B). The mean size of CIS in type B (30.45 mm) was significantly larger than in type A (18.00 mm). The mean size of SA in type A (39.46 mm) was significantly larger than in type B (19.54 mm). Most type A CIS were non‐high‐grade, and the oestrogen receptor (ER)(+)/progesterone receptor (PgR)(+)/HER2(−) immunophenotype predominated. Most type B CIS were high‐grade and six (54%) were ER(−)/PgR(−). Most type A were bcl‐2(+)/p53(−) in both SA and CIS areas, but two (18%) apocrine ductal CIS of type B were bcl‐2(−)/p53(+) in both SA and CIS areas. Expression of ER and cyclin D1 in SA was not different from that of SA unassociated with cancer. Conclusions: Most CIS involving SA arises within SA and high‐grade DCIS tends to grow beyond SA. Occasional CIS may arise outside SA and secondarily involve SA.