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Extensive retraction artefact predicts biochemical recurrence‐free survival in prostatic carcinoma
Author(s) -
Tomas Davor,
Spajić Borislav,
Milošević Milan,
Demirović Alma,
Marušić Zlatko,
Krušlin Božo
Publication year - 2011
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2011.03769.x
Subject(s) - medicine , prostatectomy , carcinoma , lymphadenectomy , interquartile range , biochemical recurrence , stage (stratigraphy) , lymph node , urology , univariate analysis , prostate , radical retropubic prostatectomy , prostate specific antigen , multivariate analysis , cancer , biology , paleontology
Tomas D, Spajić B, Milošević M, Demirović A, Marušić Z & Krušlin B
(2011) Histopathology 58 , 447–454
Extensive retraction artefact predicts biochemical recurrence‐free survival in prostatic carcinoma Aims: To determine whether the presence and extent of peritumoral retraction artefact could be used to predict biochemical recurrence‐free survival in prostatic carcinoma. Methods and results: The study included 162 consecutive patients treated by radical retropubic prostatectomy and bilateral lymphadenectomy for clinically localized prostatic carcinoma. A variable degree of retraction artefact was present in all 162 analysed tumours. The extent of retraction artefact in prostatic carcinomas ranged from 5% to 55% with a median value of 15% (interquartile range 10–25%). We found no correlation between the extent of retraction artefact in the tumours and patient’s age ( P = 0.608), preoperative ( P = 0.362) and postoperative ( P = 0.279) Gleason score or lymph node metastases ( P = 0.084). In contrast, the extent of retraction artefact correlated with high preoperative prostate‐specific antigen ( P < 0.001), short follow‐up time ( P < 0.001), seminal vesicle invasion and/or extracapsular extension of the tumour (T3 stage tumours) ( P < 0.001) and positive surgical margins ( P < 0.001). Furthermore, extensive retraction artefact was associated with poor biochemical recurrence‐free survival in both univariate ( P < 0.001) and multivariate analyses ( P = 0.013). Conclusion: The presence of extensive retraction artefact in prostatic carcinoma correlates with tumour characteristics signifying aggressive behaviour and indicates poor biochemical recurrence‐free survival.