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Flow cytometry and its use in the diagnosis and management of mature lymphoid malignancies
Author(s) -
de Tute Ruth M
Publication year - 2011
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2010.03703.x
Subject(s) - immunophenotyping , flow cytometry , pathology , biology , hematologic neoplasms , minimal residual disease , cytometry , immunology , medicine , leukemia , cancer , genetics
de Tute R M
(2011) Histopathology 58, 90–105
Flow cytometry and its use in the diagnosis and management of mature lymphoid malignancies The last decade has seen major advances in flow cytometric immunophenotyping and this has expanded the utility of flow cytometry to investigate the antigens present on normal and neoplastic haematopoietic cells. This review summarizes how flow cytometry is used currently in the diagnosis and management of mature lymphoid malignancies. The establishment of disease‐specific phenotypes allows the creation of assays which can detect neoplastic cells with high specificity and sensitivity. Certain lymphoid neoplasms are well defined immunophenotypically, while others are more heterogeneous. The availability of more sophisticated cytometers and a wider selection of antibodies in routine diagnostic laboratories will lead to the resolution of these more complex disease entities.