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Primary mucin‐producing tumours of the salivary glands: a clinicopathological and morphometric study
Author(s) -
Yakirevich Evgeny,
Sabo Edmond,
Klorin Geula,
Alos Llucia,
Cardesa Antonio,
Ellis Gary L,
Shumway Brian S,
Gnepp Douglas R
Publication year - 2010
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2010.03639.x
Subject(s) - mucin , pathology , salivary gland , medicine , biology
Yakirevich E, Sabo E, Klorin G, Alos L, Cardesa A, Ellis G L, Shumway B S & Gnepp D R
(2010) Histopathology 57, 395–409
Primary mucin‐producing tumours of the salivary glands: a clinicopathological and morphometric study Aims: To determine clinicopathological and morphometric features that discriminate between mucin‐producing primary salivary gland carcinomas. Materials and results: Fifteen mucin‐producing tumours were stratified into five colloid carcinomas (CCs), four mucinous cystadenocarcinomas (MCAs), three mucin‐rich salivary duct carcinomas (SDCs) and three mucin‐rich mucoepidermoid carcinomas (MECs). The mean patient age was 70, 58, 43 and 63 years for CC, MCA, SDC and MEC, respectively. Eleven of 15 patients were female. The majority of CC cases originated from major salivary glands; MCA showed a predilection for the minor salivary glands. No disease‐related mortality was observed in the CC group; one patient died in the MCA group, and one in the SDC group. Receiver–operating characteristic curve analysis revealed an optimal cut‐off point of 17% of the tumour cells in contact with stroma that best distinguished between the CC and MCA. Histomorphometric measurements revealed that CC was best differentiated from MCA by smaller nuclear size and more regular chromatin. Conclusions: Strict morphological criteria of CC coupled with assessment of the tumour cell/stroma relationship and the nuclear features facilitate discrimination between mucinous tumours of salivary gland.