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Update on tumours of the adrenal cortex, phaeochromocytoma and extra‐adrenal paraganglioma
Author(s) -
McNicol Anne Marie
Publication year - 2011
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2010.03613.x
Subject(s) - paraganglioma , adrenal cortex , medicine , pheochromocytoma , pathology , endocrinology
McNicol A M
(2011) Histopathology 58, 155–168
Update on tumours of the adrenal cortex, phaeochromocytoma and extra‐adrenal paraganglioma This review covers aspects of adrenal cortical tumours, phaeochromocytoma and extra‐adrenal paragangliomas. Relevant clinical and epidemiological information is included. It is now known that about 30% of paragangliomas occur in a familial setting and these new aspects of the genetic background are presented. The main diagnostic problem in both groups of tumours is the recognition of malignant potential. The uses and limitations of multifactorial histological assessment in diagnosis and prognosis are discussed. Finally, data on the molecular changes associated with tumorigenesis and tumour progression are highlighted, and how this information may contribute in future to diagnosis and prognosis.