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Fibroblast growth factor (FGF)‐23 and fetuin‐A in calcified carotid atheroma
Author(s) -
Voigt Mathias,
Fischer DagmarChristiane,
Rimpau Max,
Schareck Wolfgang,
Haffner Dieter
Publication year - 2010
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2010.03547.x
Subject(s) - fibroblast growth factor 23 , fibroblast growth factor , atheroma , fetuin , medicine , pathology , biology , biochemistry , glycoprotein , calcium , parathyroid hormone , receptor
Voigt M, Fischer D‐C, Rimpau M, Schareck W & Haffner D
(2010) Histopathology 56 , 775–788
Fibroblast growth factor (FGF)‐23 and fetuin‐A in calcified carotid atheroma Aims: Human atheroma calcification occurs secondary to repetitive injury/remodelling of the vessel wall and might be initiated by adherence of mineral‐loaded fetuin‐A whether or not professional matrix mineralizing cells are present. The aim was to investigate the contribution of fibroblast growth factor (FGF)‐23 to ectopic mineralization. Methods and results: Serial sections of formalin‐fixed paraffin‐embedded human carotid atheroma ( n = 54) were investigated with respect to (i) size and distribution of calcific deposits, (ii) indicators of chondrogenic/osteogenic transformation, and (iii) expression of fetuin‐A and FGF‐23. All specimens were calcified and SOX‐9, collagen type II, cathepsin‐K, fetuin‐A and FGF‐23 expression was seen in 46, 53, 53, 54 and 48 specimens, respectively. The intracellular detection of FGF‐23 (45/48) indicates local synthesis. Whereas fetuin‐A expression was seen also within areas of vascular smooth muscle actin‐positive cells adjacent to calcific deposits, FGF‐23 expression was apparently restricted to the mineralization‐prone areas. Both local expression and FGF‐23 serum concentrations were significantly associated with the degree of atheroma calcification. Conclusions: Besides the induction of bone islets and subsequent mineral deposition, severe remodelling of the vessel wall is sufficient to create a mineralizable fetuin‐A‐attracting microenvironment. FGF‐23 might contribute to the formation of proper mineral, i.e. control local phosphate concentration.