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Expression of the extracellular matrix protein periostin in liver tumours and bile duct carcinomas
Author(s) -
Riener MarcOliver,
Fritzsche Florian R,
Soll Christopher,
Pestalozzi Bernhard C,
ProbstHensch Nicole,
Clavien PierreAlain,
Jochum Wolfram,
Soltermann Alex,
Moch Holger,
Kristiansen Glen
Publication year - 2010
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2010.03527.x
Subject(s) - periostin , stromal cell , pathology , extracellular matrix , cancer research , immunohistochemistry , medicine , biology , microbiology and biotechnology
Riener M‐O, Fritzsche F R, Soll C, Pestalozzi B C, Probst‐Hensch N, Clavien P‐Alain, Jochum W, Soltermann A, Moch H & Kristiansen G
(2010) Histopathology 56 , 600–606 Expression of the extracellular matrix protein periostin in liver tumours and bile duct carcinomasAims: To study the relevance of periostin, known to be involved in epithelial–mesenchymal transition (EMT), in hepatocellular and bile duct cancer. Methods and results: Immunohistochemical periostin expression was semiquantitatively analysed in normal liver tissue ( n = 20), hepatocellular carcinoma (HCC; n = 91), liver‐cell adenoma ( n = 9), focal nodular hyperplasia ( n = 13) and bile duct carcinomas (BDC; n = 116) using tissue microarrays. Normal bile ducts, gallbladder epithelium and hepatocytes showed weak cytoplasmic periostin expression. In HCC, there was strong epithelial periostin expression in 19/91 (20.9%) and strong stromal periostin expression in 10/91 cases (11%). Epithelial expression in tumour cells was significantly associated with a higher tumour grade ( P < 0.05) and hepatitis B virus infection ( P = 0.007). Importantly, there was no strong periostin expression in benign liver tumours. Strong stromal periostin expression was detected in 78/116 (67.2%) BDC and strong epithelial expression in 39/116 (33.6%) BDC. pT stage, differentiation grade and proliferation rate in primary BDC were independent of periostin expression. Epithelial periostin expression was associated with reduced overall survival on univariate and multivariate analysis. Conclusions: The EMT protein periostin is expressed in the stroma and epithelium of a subset of BDC and HCC. Epithelial periostin expression is a marker for malignant transformation of hepatocytes and a novel prognostic marker in BDC.