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Comparison of margin assessment by radial and shave sections in wide local excision specimens for invasive carcinoma of the breast
Author(s) -
Hodi Zsolt,
Ellis Ian O,
Elston Christopher W,
Pinder Sarah E,
Donovan Glynn,
Macmillan R Douglas,
Lee Andrew H S
Publication year - 2010
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2010.03518.x
Subject(s) - margin (machine learning) , frozen section procedure , carcinoma , breast carcinoma , surgical margin , medicine , residual , nuclear medicine , surgery , breast cancer , pathology , cancer , resection , mathematics , machine learning , computer science , algorithm
Hodi Z, Ellis I O, Elston C W, Pinder S E, Donovan G, Macmillan R D & Lee A H S
(2010) Histopathology 56 , 573–580 Comparison of margin assessment by radial and shave sections in wide local excision specimens for invasive carcinoma of the breast Aims: Standard margin assessment of breast carcinoma surgical specimens uses radial sections perpendicular to the margin. Shave sections assess a larger surface area of margin than radial sections. The aim was to assess the value of additional shave sections of the margin. Methods and results: Both types of section were used to assess 471 wide local excision specimens for invasive carcinoma. One hundred and seventy‐nine specimens had positive margins: only radial margins were involved (tumour within 5 mm of margin) in 76, only shave margins in 45, and both shave and radial margins in 58. Residual carcinoma was found in re‐excision specimens (immediate or later) in 43% when the closest distance to the radial margin was 0–1 mm, 25% for 2–4 mm, 18% for 5–9 mm and 13% for >9 mm. Residual carcinoma was found in 44% of specimens if any shave section was positive and in 9% if all shaves were negative. Residual carcinoma was found in 32% if either radial or shave sections were positive and in 4% if neither was positive. Conclusions: The combination of radial and shave sections appears to be good at separating patients into two groups with high and low risk of residual carcinoma.