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Bone marrow necrosis related to paracoccidioidomycosis: the first eight cases identified at autopsy
Author(s) -
Resende Lucilene S R,
Mendes Rinaldo P,
Bacchi Maura M,
Marques Sílvio A,
Barraviera Benedito,
Souza Lenice R,
Meira Domingos A,
NiéroMelo Lígia
Publication year - 2009
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2009.03245.x
Subject(s) - paracoccidioidomycosis , paracoccidioides brasiliensis , pathology , medicine , bone marrow , autopsy , necrosis , cytology , histology , biopsy , paracoccidioides
Aims: To report the first eight bone marrow necrosis (BMN) cases related to paracoccidioidomycosis (PCM) from patient autopsies with well‐documented bone marrow (BM) histology and cytology. Methods and results: A retrospective evaluation was performed on BM specimens from eight autopsied patients from Botucatu University Hospital with PCM‐related BMN. Relevant BMN literature was searched and analysed. Conclusions: All eight patients had acute PCM. Six had histological only (biopsies) and two cytological only (smears) specimens. Five biopsy specimens revealed severe and one mild coagulation patterned necrotic areas. Five had osteonecrosis. The cytological specimens also showed typical BMN patterns. Paracoccidioides brasiliensis yeast forms were visible within necrotic areas in all cases.