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Nerve growth factor receptor (p75 NTR ) and pattern of invasion predict poor prognosis in oral squamous cell carcinoma
Author(s) -
Søland T M,
Brusevold I J,
Koppang H S,
Schenck K,
Bryne M
Publication year - 2008
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2008.03063.x
Subject(s) - grading (engineering) , pathology , immunohistochemistry , metastasis , low affinity nerve growth factor receptor , proportional hazards model , medicine , survival analysis , basal cell , receptor , biology , oncology , cancer research , nerve growth factor , cancer , ecology
Aims: To evaluate the expression of p75 neurotrophin receptor (p75 NTR ) in oral squamous cell carcinoma (OSCC). The results were related to tumour node metastasis (TNM) stage, World Health Organization (WHO) grade, invasive front grading (IFG) and prognosis. Methods and results: Immunohistochemically, the expression of p75 NTR was assessed in 53 T1‐T2 OSCCs. Clinical data were recorded prospectively. The end‐point was disease‐free survival. All tumours expressed p75 NTR , and this expression, both in central/superficial tumour areas and at the invasive front, was associated with poor prognosis ( P = 0.03 and P = 0.02) (log rank test). Tumours with marked cellular dissociation (IFG parameter) had more recurrences than tumours with collective tumour cell invasion ( P = 0.03). In tumours showing both p75 NTR at the invasive front and marked tumour cell dissociation, the average risk of recurrence was increased about 17 times (Cox regression analysis) compared with tumours with low p75 NTR expression and collective invasion. Traditional prognostic systems were of no prognostic significance. Conclusion: p75 NTR was expressed in all OSCCs. p75 NTR expression and the pattern of invasion were significantly associated with a poor prognosis in OSCCs, and both were better prognostic factors than traditional prognostic parameters. The combination of p75 NTR expression and the pattern of invasion strongly increased precision in the identification of tumours with poor disease‐free survival.