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Chromogranin A expression correlates with tumour cell type and prognosis in signet ring cell carcinoma of the stomach
Author(s) -
Fujiyoshi Y,
Eimoto T
Publication year - 2008
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2007.02950.x
Subject(s) - chromogranin a , signet ring cell , signet ring cell carcinoma , immunohistochemistry , pathology , stomach , medicine , neuroendocrine differentiation , cell , metastasis , carcinoma , stage (stratigraphy) , oncology , cancer , biology , adenocarcinoma , prostate cancer , genetics , paleontology
Aims: To investigate neuroendocrine (NE) differentiation in gastric signet ring cell carcinoma (SRCC) using chromogranin A (CgA) as an indicator of a well‐differentiated NE phenotype and to determine its relationship to cell type, stage and prognosis. Methods and results: 102 SRCCs were categorized into five subtypes according to the predominant cell type in the World Health Organization classification. 38 cases (37.3%) showed focal or diffuse CgA positivity. The positive cells were mostly histiocytoid and eosinophilic SRCC cells and some were classical SRCC cells. Small cell and anaplastic‐type SRCC cells were only rarely immunopositive. There was no significant relationship between CgA expression and the extent of invasion or presence of metastasis. However, a significant positive correlation existed between CgA positivity and favourable prognosis, with a tendency for greater positivity to be associated with better overall survival. Multivariate analysis showed expression of CgA to be an independent prognostic factor. Conclusion: CgA expression is restricted to certain tumour cell types and may help to predict prognosis in gastric SRCCs.