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Clinicopathological significance of survivin expression in patients with hepatocellular carcinoma
Author(s) -
Chau GY,
Lee A FY,
Tsay SH,
Ke YR,
Kao HL,
Wong FH,
Tsou AP,
Chau YP
Publication year - 2007
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2007.02738.x
Subject(s) - survivin , hepatocellular carcinoma , immunohistochemistry , carcinogenesis , cancer research , messenger rna , inhibitor of apoptosis , clinical significance , medicine , pathology , carcinoma , biology , oncology , apoptosis , cancer , gene , programmed cell death , biochemistry
Aims: Survivin, a newly discovered member of the inhibitor of apoptosis protein family, is suggested to be involved in liver carcinogenesis. The aim was to investigate the clinical significance of survivin expression in resected hepatocellular carcinoma (HCC) and paired adjacent non‐tumour tissue. Methods and results: Immunohistochemistry, reverse transcriptase‐polymerase chain reaction and Western blots were used to examine survivin mRNA and protein levels in 94 specimens of HCC tissues at different TNM stages and the data were correlated with the clinicopathological profiles. Patients were categorized into those with high tumour survivin protein levels (T–N ≥ −1) and those with low levels (T–N < −1). Follow‐up data were collected prospectively. mRNA levels of survivin and its splice variants in tumour tissue were significantly higher than in paired non‐tumour tissue. However, survivin protein levels in paired non‐tumour tissue were significantly higher than in tumour tissue from all three TNM stages. Additionally, high tumour survivin protein levels (T–N ≥ −1) correlated with a better prognosis and low levels (T–N < −1) with a worse survival rate. Conclusions: High cytoplasmic survivin protein levels in HCC tissues seem to be an indicator of better prognosis in HCC patients after resection.