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Cyclin A expression and its diagnostic value in pleomorphic adenoma and carcinoma expleomorphic adenoma of the parotid gland
Author(s) -
Patel R S,
Hughes C W,
Fredericks S,
Lee C S,
Rose B,
Gao K,
Smith G,
Hong A,
O'Brien C J
Publication year - 2007
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2007.02729.x
Subject(s) - carcinoma ex pleomorphic adenoma , adenoma , pleomorphic adenoma , pathology , immunohistochemistry , cyclin d1 , cancer research , pathological , medicine , salivary gland , cell cycle , cancer
Aims: To investigate cyclin A expression in pleomorphic adenoma (PA) and carcinoma expleomorphic adenoma (CXPA) of the parotid gland with a view to assessing its potential value as a diagnostic marker for CXPA. Methods and results: Cyclin A expression in PA and CXPA was studied using semiquantitiative immunohistochemistry. The epithelial component of the tumours expressed cyclin A in a statistically significantly ( P < 0.005) higher number of CXPA cases (86%) compared with the PA cases (39%). Cyclin A was not expressed in normal salivary tissues of PA and CXPA. Conclusions: High cyclin A expression is a useful marker for the pathological diagnosis of CXPA.